serum uric acid level and diverse impacts on regional arterial stiffness and wave reflection

نویسندگان

suyan bian

hongyang guo

ping ye

leiming luo

چکیده

background: both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. little is known about the relations of serum uric acid (ua) level to regional arterial stiffness and wave reflection. the aim of the study was to investigate the gender-specific association of serum ua and indices of arterial function in a community-based investigation in china. methods: cross-sectional data from 2374 adults (mean age 58.24 years) who underwent routine laboratory tests, regional pulse wave velocity (pwv) and pulse wave analysis measurements were analyzed in a gender-specific manner. none of the participants had atherosclerotic cardiovascular disease, chronic renal failure, systemic inflammatory disease, gout, or were under treatment which would affect serum ua level. results: men had higher serum ua level than women. subjects with hyperuricaemia had significantly higher carotid-ankle pwv in both genders (p< 0.05), and the carotid-femoral pwv (pwvc-f) was higher in women (p< 0.001) while the augmentation index was marginally lower in men (p = 0.049). multiple regression analysis showed that serum ua was an independent determinant only for pwvc-f in women (β = 0.104, p = 0.027) when adjusted for atherogenic confounders. no other independent relationship was found between ua level and other surrogates of arterial stiffness. conclusions: serum ua levels are associated with alterations in systemic arterial stiffness that differ in men and women. women might be more susceptible to large vascular damage associated with hyperuricaemia.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection

BACKGROUND Both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. Little is known about the relations of serum uric acid (UA) level to regional arterial stiffness and wave reflection. The aim of the study was to investigate the gender-specific association of serum UA and indices of arterial function in a community-based investigation in China. ...

متن کامل

Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease

OBJECTIVE Total bilirubin (TB) was recently recognized as an endogenous anti-inflammatory and anti-oxidant molecule. Uric acid (UA) takes part in cardiovascular diseases by inducing oxidative stress, inflammation, and endothelial dysfunction. We assessed the relationship between serum TB levels, serum UA levels, and inflammatory status assessed by neutrophil-to-lymphocyte ratio (N/L) and arteri...

متن کامل

Arterial Stiffness Arterial Stiffness and Wave Reflection Sex Differences and Relationship With Left Ventricular Diastolic Function

Increased arterial stiffness and wave reflection have been reported in heart failure with normal ejection fraction (HFNEF) and in asymptomatic left ventricular (LV) diastolic dysfunction, a precursor of HFNEF. It is unclear whether women, who have higher frequency of HFNEF, are more vulnerable than men to the deleterious effects of arterial stiffness on LV diastolic function. We investigated, i...

متن کامل

The Impacts of Serum Uric Acid on arterial hemodynamics and Cardiovascular Risks.

UNLABELLED Hyperuricemia, and its clinical manifestation gout, is a metabolic disease process that has been recognized since the dawn of medical inquiry. Uric acid was hypothesized to be a mediator of cardiovascular disease for period of time. Epidemiological correlations of hyperuricemia with hypertension and cardiovascular events were evident for two centuries' studies. With recent animal stu...

متن کامل

Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in Korean

BACKGROUND AND OBJECTIVES Associations have been reported between the serum uric acid (SUA) level, metabolic syndrome (MS), and atherosclerosis. We have determined the relationship between the SUA level, MS, and arterial stiffness in Korean. SUBJECTS AND METHODS Cross-sectional data from 1,276 adults who underwent routine laboratory tests and pulse wave velocity (PWV) measurements during a he...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of public health

جلد ۴۱، شماره ۸، صفحات ۳۳-۴۱

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023